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Post by Cleburneslim on Aug 19, 2020 15:12:38 GMT -6
I would like to add lupus and arthritis patients are routinely prescribed 800mg Ibuprofen to treat occurrences of inflammation and are regularly given steroid injections.
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Post by King_Gamecock on Aug 20, 2020 6:50:59 GMT -6
You simply are wrong. Hydroxychloroquine Common brands: Plaquenil Overview Description Immunosuppressive drug and Anti-parasite It can treat and prevent malaria. It can also treat lupus and arthritis. Brands: Plaquenil Availability: Prescription needed Pregnancy: No known risks Alcohol: Interactions can occur Drug class: Quinoline It does not work to reduce Inflammation it works to prevent it by suppressing a patient's immune response, thus preventing the occurrence of a flare and Inflammation. It will not end or treat a fever headache or any other Inflammation. As you may already know sle lupus and arthritis are autoimmune diseases and this is the reason it treats these diseases by suppressing a persons own immune system and preventing a person's own body from attacking itself. Note that it works to prevent and not to treat a flare. Okay... whatever: pubmed.ncbi.nlm.nih.gov/8546725/The antiinflammatory and antiviral effects of hydroxychloroquine in two patients with acquired immunodeficiency syndrome and active inflammatory arthritis M H Ornstein 1, K Sperber Affiliations expand PMID: 8546725 DOI: 10.1002/art.1780390122 Abstract Objective: To report the antiinflammatory and antiviral effects of hydroxychloroquine (HCQ) treatment in 2 patients with AIDS and inflammatory arthritis. Methods: Two patients with AIDS and inflammatory arthritis were treated with HCQ, which was given in a loading dose of 600 mg/day. The maintenance dosage was calculated to remain below 6.5 mg/kg/day. Both patients had initial T cell subset studies; 1 patient, had serum and plasma collected before and after 1 year of HCQ treatment. Assays were performed for T cell subsets, recoverable human immunodeficiency virus type 1 (HIV-1) RNA, mitogen- and antigen-specific proliferation, and interleukin-6 (IL-6) levels. New studies on the use of HCQ as an anti-HIV-1 agent are reviewed. Results: Both patients had a dramatic decrease in their arthritis activity. Neither patient required immunosuppressive therapy or developed an opportunistic infection. In the patient who was studied after 1 year of therapy, there was a 1-log decrease in recoverable HIV-1 RNA, improved mitogen- and antigen-specific immune responses, and a large decrease in the IL-6 level while taking HCQ. Recent in vitro and in vivo assays in patients with HIV infection have shown similar antiviral and antiinflammatory effects from HCQ. Conclusion: HCQ may exert simultaneous anti-inflammatory and antiviral effects in patients with HIV infection and inflammatory arthritis. If larger studies confirm this observation, it may be the drug of choice in this population of patients. www.rheumatology.org/I-Am-A/Patient-Caregiver/Treatments/Hydroxychloroquine-PlaquenilHydroxychloroquine (Plaquenil) medication bottles Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis (or juvenile idiopathic arthritis) and other autoimmune diseases. It is not clear why hydroxychloroquine is effective at treating autoimmune diseases. It is believed that hydroxychloroquine interferes with the communication of cells in the immune system. arthritis-research.biomedcentral.com/articles/10.1186/s13075-019-2040-6Hydroxychloroquine (HCQ) exerts various anti-inflammatory and immunomodulatory effects and is widely used for the treatment of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) [1]. However, its mode of action is not completely understood [2]. According to the previous studies, the actions of HCQ on the immune system appear to involve its ability to interfere with lysosomal acidification and thereby affect antigen processing and Toll-like receptor (TLR) signaling [2,3,4]. The NLRP3 inflammasome is a cytoplasmic macromolecular complex that orchestrates inflammatory responses in innate immunity by inducing caspase-1 activation and IL-1β processing [5]. Various danger signals, including reactive oxygen species (ROS), crystals, potassium efflux, and amyloid proteins, have been identified as possible activators of the NLRP3 inflammasome [6]. Recent studies demonstrated the pivotal roles of SAA in the regulation of immunity and inflammation. Cytokine-like activities of SAA for its induction of IL-1β, TNFα, and IL-8 had been demonstrated. The engagement of formyl peptide receptor-like 1 (FPRL1) by its ligand, SAA, initiates intracellular signaling such as nuclear factor-κB, leading to an activation of the innate immunity that is crucial to the development of inflammation [7]. Also, SAA has been identified as an endogenous activator of the NLRP3 inflammasome, which is critical for pro-IL-1β processing and activation [8]. Collectively, these findings illustrate proinflammatory functions of SAA including inflammasome activation. This last one is the primary benefit to Covid-19 treatment. In some cases, the inflammation caused by Coronavirus can cause cytokine storm and that will result in rapid death. Also, the acidification of the lysosome is what inhibits viral replication. That said, there are many many other medications that accomplish the same exact thing without cardiac risk. You're not arguing with me, you're arguing with these research reports. They clearly state in both plain and scientific language, that HCQ is anti-inflammatory, and even spell out the mechanics of how it effects the NLRP3 inflammasome. I am not wrong.
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Post by King_Gamecock on Aug 20, 2020 6:53:59 GMT -6
I would like to add lupus and arthritis patients are routinely prescribed 800mg Ibuprofen to treat occurrences of inflammation and are regularly given steroid injections. Which is why doctors have opted for that treatment course for Covid patients. It has been widely reported that steroids and anti-inflammatory drugs are a safer course of treatment than HCQ because they do the same thing with lower risk of adverse side effects.
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Post by gemofthehills on Aug 20, 2020 7:12:47 GMT -6
Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis (or juvenile idiopathic arthritis) and other autoimmune diseases. It is not clear why hydroxychloroquine is effective at treating autoimmune diseases. It is believed that hydroxychloroquine interferes with the communication of cells in the immune system.
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Post by Cleburneslim on Aug 27, 2020 16:57:24 GMT -6
The side effects of plaquenil are greatly exaggerated recently. It is a very safe drug used over the past 60 yrs or so. Not to belittle steriods but if you take them regularly they can be very dangerous. I lost a brother in law to oral steriod use for his knees. While my wife has been taking plaquenil for years without a hiccup. It does not reduce inflammation. It lowers ones immune response.
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Post by Cleburneslim on Aug 27, 2020 17:06:19 GMT -6
6]. Recent studies demonstrated the pivotal roles of SAA in the regulation of immunity and inflammation. Cytokine-like activities of SAA for its induction of IL-1β, TNFα, and IL-8 had been demonstrated. The engagement of formyl peptide receptor-like 1 (FPRL1) by its ligand, SAA, initiates intracellular signaling such as nuclear factor-κB, leading to an activation of the innate immunity that is crucial to the development of inflammation [7]. Also, SAA has been identified as an endogenous activator of the NLRP3 inflammasome, which is critical for pro-IL-1β processing and activation [8]. Collectively, these findings illustrate proinflammatory functions of SAA including inflammasome activation.
Note the way in which hcq reduces the inflammation process.
The engagement of formyl peptide receptor-like 1 (FPRL1) by its ligand, SAA, initiates intracellular signaling such as nuclear factor-κB, leading to an activation of the innate immunity that is crucial to the development of inflammation
You are wrong. I also find it amusing that you would use a study that shows efficacy against a virus to prove it has no antiviral properties but is simply an anti-inflammatory.
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